diff --git a/awx/api/serializers.py b/awx/api/serializers.py
index e916550d82..102be782f0 100644
--- a/awx/api/serializers.py
+++ b/awx/api/serializers.py
@@ -4143,8 +4143,24 @@ class LaunchConfigurationBaseSerializer(BaseSerializer):
 
         # Build unsaved version of this config, use it to detect prompts errors
         mock_obj = self._build_mock_obj(attrs)
-        if set(list(ujt.get_ask_mapping().keys()) + ['extra_data']) & set(attrs.keys()):
-            accepted, rejected, errors = ujt._accept_or_ignore_job_kwargs(_exclude_errors=self.exclude_errors, **mock_obj.prompts_dict())
+        ask_mapping_keys = set(ujt.get_ask_mapping().keys())
+        requested_prompt_fields = set(attrs.keys()) & ask_mapping_keys
+        if 'extra_data' in attrs:
+            requested_prompt_fields.add('extra_vars')
+
+        # prompts_dict() pulls persisted M2M state (labels, credentials,
+        # instance_groups) via the instance pk.  Only re-validate the full prompt
+        # state when the caller is switching the underlying template; otherwise
+        # restrict validation to the fields the request explicitly provided.
+        if 'unified_job_template' in attrs:
+            prompts_to_validate = mock_obj.prompts_dict()
+        elif requested_prompt_fields:
+            prompts_to_validate = {k: v for k, v in mock_obj.prompts_dict().items() if k in requested_prompt_fields}
+        else:
+            prompts_to_validate = None
+
+        if prompts_to_validate is not None:
+            accepted, rejected, errors = ujt._accept_or_ignore_job_kwargs(_exclude_errors=self.exclude_errors, **prompts_to_validate)
         else:
             # Only perform validation of prompts if prompts fields are provided
             errors = {}
diff --git a/awx/main/tests/functional/api/test_workflow_node.py b/awx/main/tests/functional/api/test_workflow_node.py
index 71874085d7..02860d06b6 100644
--- a/awx/main/tests/functional/api/test_workflow_node.py
+++ b/awx/main/tests/functional/api/test_workflow_node.py
@@ -13,6 +13,7 @@ from awx.main.models.workflow import (
     WorkflowJobTemplateNode,
 )
 from awx.main.models.credential import Credential
+from awx.main.models.label import Label
 from awx.main.scheduler import TaskManager, WorkflowManager, DependencyManager
 
 # Django
@@ -51,6 +52,31 @@ def test_node_accepts_prompted_fields(inventory, project, workflow_job_template,
     post(url, {'unified_job_template': job_template.pk, 'limit': 'webservers'}, user=admin_user, expect=201)
 
 
+@pytest.mark.django_db
+def test_node_extra_data_patch_with_unprompted_labels(inventory, project, organization, workflow_job_template, patch, admin_user):
+    """AAP-41742: PATCH extra_data on a workflow node should succeed even when
+    the node has labels associated but the JT has ask_labels_on_launch=False."""
+    jt = JobTemplate.objects.create(
+        inventory=inventory,
+        project=project,
+        playbook='helloworld.yml',
+        ask_variables_on_launch=True,
+        ask_labels_on_launch=False,
+    )
+    label = Label.objects.create(name='repro-label', organization=organization)
+
+    node = WorkflowJobTemplateNode.objects.create(
+        workflow_job_template=workflow_job_template,
+        unified_job_template=jt,
+        extra_data={'foo': 'bar'},
+    )
+    node.labels.add(label)
+
+    url = reverse('api:workflow_job_template_node_detail', kwargs={'pk': node.pk})
+    r = patch(url, {'extra_data': {'foo': 'edited'}}, user=admin_user, expect=200)
+    assert r.data['extra_data'] == {'foo': 'edited'}
+
+
 @pytest.mark.django_db
 @pytest.mark.parametrize(
     "field_name, field_value",