diff --git a/config/wsgi.py b/config/wsgi.py
index 9999eb08c8..c053481836 100644
--- a/config/wsgi.py
+++ b/config/wsgi.py
@@ -1 +1,4 @@
+import sys
+if sys.prefix != '/var/lib/awx/venv/tower':
+    raise RuntimeError('Tower virtualenv not activated. Check WSGIPythonHome in Apache configuration.')
 from awx.wsgi import application  # NOQA