diff --git a/Makefile b/Makefile
index 1f577e3164..8744274163 100644
--- a/Makefile
+++ b/Makefile
@@ -16,6 +16,7 @@ DEPS_SCRIPT ?= packaging/bundle/deps.py
 GIT_BRANCH ?= $(shell git rev-parse --abbrev-ref HEAD)
 
 VENV_BASE ?= /tower_devel/venv
+SCL_PREFIX ?=
 
 CLIENT_TEST_DIR ?= build_test
 
@@ -109,6 +110,7 @@ MOCK_CFG ?=
 RPM_SPECDIR= packaging/rpm
 RPM_SPEC = $(RPM_SPECDIR)/$(NAME).spec
 RPM_DIST ?= $(shell rpm --eval '%{?dist}' 2>/dev/null)
+
 # Provide a fallback value for RPM_DIST
 ifeq ($(RPM_DIST),)
     RPM_DIST = .el6
@@ -118,7 +120,17 @@ RPM_ARCH ?= $(shell rpm --eval '%{_arch}' 2>/dev/null)
 ifeq ($(RPM_ARCH),)
     RPM_ARCH = $(shell uname -m)
 endif
-RPM_NVR = $(NAME)-$(VERSION)-$(RELEASE)$(RPM_DIST)
+
+# Software collections settings if on EL6
+ifeq ($(RPM_DIST),.el6)
+    SCL_PREFIX = python27-
+    SCL_DEFINES = --define 'scl python27'
+else
+    SCL_PREFIX =
+    SCL_DEFINES =
+endif
+
+RPM_NVR = $(SCL_PREFIX)$(NAME)-$(VERSION)-$(RELEASE)$(RPM_DIST)
 
 # TAR Bundle build parameters
 DIST = $(shell echo $(RPM_DIST) | sed -e 's|^\.\(el\)\([0-9]\).*|\1|')
@@ -701,7 +713,7 @@ rpmtar: sdist rpm-build/$(SDIST_TAR_FILE)
 
 rpm-build/$(RPM_NVR).src.rpm: /etc/mock/$(MOCK_CFG).cfg
 	$(MOCK_BIN) -r $(MOCK_CFG) --resultdir rpm-build --buildsrpm --spec rpm-build/$(NAME).spec --sources rpm-build \
-	   --define "tower_version $(VERSION)" --define "tower_release $(RELEASE)"
+	   --define "tower_version $(VERSION)" --define "tower_release $(RELEASE)" $(SCL_DEFINES)
 
 mock-srpm: rpmtar rpm-build/$(RPM_NVR).src.rpm
 	@echo "#############################################"
@@ -711,7 +723,7 @@ mock-srpm: rpmtar rpm-build/$(RPM_NVR).src.rpm
 
 rpm-build/$(RPM_NVR).$(RPM_ARCH).rpm: rpm-build/$(RPM_NVR).src.rpm
 	$(MOCK_BIN) -r $(MOCK_CFG) --resultdir rpm-build --rebuild rpm-build/$(RPM_NVR).src.rpm \
-	   --define "tower_version $(VERSION)" --define "tower_release $(RELEASE)"
+	   --define "tower_version $(VERSION)" --define "tower_release $(RELEASE)" $(SCL_DEFINES)
 
 mock-rpm: rpmtar rpm-build/$(RPM_NVR).$(RPM_ARCH).rpm
 	@echo "#############################################"
@@ -843,9 +855,11 @@ packaging/packer/ansible-tower-$(VERSION)-vmx/ansible-tower-$(VERSION).vmx: pack
 # TODO - figure out how to build the front-end and python requirements with
 # 'build'
 build:
+	export SCL_PREFIX
 	$(PYTHON) setup.py build
 
 install:
+	export SCL_PREFIX
 	$(PYTHON) setup.py install $(SETUP_INSTALL_ARGS)
 
 # Docker Compose Development environment
diff --git a/setup.py b/setup.py
index 3c46b87f00..2468ef5cae 100755
--- a/setup.py
+++ b/setup.py
@@ -17,26 +17,29 @@ if os.getenv('OFFICIAL', 'no') == 'yes':
 else:
     build_timestamp = '-' + os.getenv("BUILD", datetime.datetime.now().strftime('0.git%Y%m%d%H%M'))
 
+# Path prefix for when we're running under a software collection
+scl_prefix = os.getenv('SCL_PREFIX', '')
+
 # Paths we'll use later
-etcpath = "/etc/tower"
+etcpath = scl_prefix + "/etc/tower"
 homedir = "/var/lib/awx"
-sharedir = "/usr/share/awx"
-bindir = "/usr/bin"
-docdir = "/usr/share/doc/ansible-tower"
+sharedir = scl_prefix + "/usr/share/awx"
+bindir = scl_prefix + "/usr/bin"
+docdir = scl_prefix + "/usr/share/doc/ansible-tower"
 munin_plugin_path = "/etc/munin/plugins/"
 munin_plugin_conf_path = "/etc/munin/plugin-conf.d"
 
 if os.path.exists("/etc/debian_version"):
-    sysinit = "/etc/init.d"
-    webconfig  = "/etc/apache2/conf.d"
+    sysinit = scl_prefix + "/etc/init.d"
+    webconfig  = scl_prefix + "/etc/apache2/conf.d"
     shutil.copy("config/awx-munin-ubuntu.conf", "config/awx-munin.conf")
     # sosreport-3.1 (and newer) look in '/usr/share/sosreport/sos/plugins'
     # sosreport-3.0 looks in '/usr/lib/python2.7/dist-packages/sos/plugins'
     # debian/<package>.links will create symlinks to support both versions
     sosconfig = "/usr/share/sosreport/sos/plugins"
 else:
-    sysinit = "/etc/rc.d/init.d"
-    webconfig  = "/etc/httpd/conf.d"
+    sysinit = scl_prefix + "/etc/rc.d/init.d"
+    webconfig  = scl_prefix + "/etc/httpd/conf.d"
     shutil.copy("config/awx-munin-el.conf", "config/awx-munin.conf")
     # The .spec will create symlinks to support multiple versions of sosreport
     sosconfig = "/usr/share/sosreport/sos/plugins"